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ea0035p650 | Female reproduction | ECE2014

Relevance of estrogen activating STS and inactivating SULT1E1 enzymes and estrogen receptors α/β in patients with advanced ovarian cancer

Mungenast Felicitas , Aust Stefanie , Svoboda Martin , Ocko Katharina , Klameth Lukas , Castilo-Tong Dan Cacsire , Zeillinger Robert , Van Gorp Toon , Vergote Ignace , Braicu Ioana , Sehouli Jalid , Mahner Sven , Fogel M , Thalhammer Theresia

Background: By regulating the concentration of active estrogens in tumor cells, steroid hormone-inactivating estrogen sulfotransferase (SULT1E1) and estrogen activating steroid sulfatase (STS) may influence the progression of EOC. Therefore, we determined the expression and prognostic impact of both enzymes together with the ERα/β and the progesterone receptor (PGR) in this tumor entity.Methods: The mRNA expression levels of STS, SULT1E1, ER&#9...

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Endocrine Abstracts

Relevance of estrogen activating STS and inactivating SULT1E1 enzymes and estrogen receptors α/β in patients with advanced ovarian cancer

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